Tecan solutions enable both the characterization of epigenetic changes in the DNA and the elucidation of the impact of those alterations on gene expression. Our Methyl-Seq Systems allow investigation of direct methylation of DNA via bisulfite sequencing while our Ovation® Ultralow Library Systems enable fast library construction for ChIP-Seq, FAIRE-Seq, Hi-C and more. Used in conjunction with our RNA-Seq library systems, researchers can probe both epigenetic modifications of interest and their associated gene expression changes.
Researchers have found evidence that suggests different cytosine modifications are functionally distinct and thus should be studied independently to better understand their biological impact. To distinguish cytosine DNA modifications, Tecan has partnered with CEGX to combine our Methyl-Seq NGS library prep kits with CEGX's TrueMethyl® to enable accurate quantification of 5mC and 5hmC in parallel at single-base resolution.
Learn more about distinguishing DNA modifications here.