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Sample preparation for mass spectrometry

Reduced operating costs

Clinical and toxicology laboratories are performing ever-increasing numbers of mass spectrometry-based assays, forcing them to address the major bottleneck in their workflows – manual sample preparation. Tecan provides tailored workflow automation solutions combining precise liquid handling with an in-depth understanding of major extraction technologies.

Related products:  Liquid handling and automation
Positive pressure SPE
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Positive pressure solid phase extraction

SPE cartridges are used in a broad variety of labs – hospitals, toxicology service labs performing medicolegal drug testing, CROs doing bioanalytical/bioequivalence studies, and food contaminant testing labs.

The manual process is very labor-intensive, meaning technicians are prone to RSI and are routinely exposed to hazardous solvents. Human errors lead to lower TATs and more repeat tests, resulting in higher costs and lower overall efficiency.

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Protein affinity capture tips

Mass spectrometry is becoming the tool of choice for biomarker research, due to its sensitivity, accuracy and ability to resolve PTMs. However, conventional enrichment and concentration methods for MS analysis can be labor-intensive and unreliable.

MSIA™ (Mass Spectrometric Immunoassay) Streptavidin EVO micro columns represent the next generation of affinity microcolumns, with the ability to capture and concentrate low abundance proteins from various sample types.

Highlights

  • One-stop solution
  • Affinity purification of large molecules
  • Fully automatable in a 96-tip format

Brochures

Automated positive pressure SPE workstation

Easy automation of manual SPE methods using the Freedom EVO positive pressure SPE workstation reduces overall solvent consumption and operator exposure to hazardous solvents, with an intuitive TouchTools™ graphical user interface to minimize the need for user training.

Automated sample preparation for mass spectrometry

End-to-end sample preparation for mass spectrometry using the Freedom EVO platform. Automate even the most challenging protocols, eliminating the bottleneck of manual sample preparation.

Application Notes

Next Generation Large Molecule Bioanalysis Simplified

Overcoming the challenges associated with affinity purification methods using the Thermo Scientific MSIA™ workflow on the Freedom EVO® platform. This solution combines robust and high throughput liquid handling with MSIA Streptavidin EVO microcolumns for fast and accurate isolation of target analytes from complex biological matrices.

A Universal LB-MSIA workflow using Freedom EVO platform for the Quantitative Analysis of Intact Therapeutic Antibodies of Different Allotype Subclasses

This workflow combines the Freedom EVO platform with MSIA Streptavidin EVO microcolumns and biotin-conjugated anti-IgG Fc affinity ligands to provide a highly sensitive and reproducible method for the quantitative analysis of human IgG mAbs of different subclasses. All the pre-analytical steps are performed on the Freedom EVO, using the MCA 96 for high throughput processing.

A universal LB-MSIA™ workflow using Freedom EVO platform for the pre-clinical analysis of therapeutic antibodies of differing allotypes in rodent plasma

Combining the Freedom EVO platform with the MSIA Streptavidin EVO microcolumns enables the characterization of multiple intact mAbs over a wide dynamic range.

Automated SPE Method Development Using Strata™-X 96-Well SPE Method Development Plates In Conjunction with a Tecan Freedom EVO® Liquid Handling System

SPE sorbent screening with the Freedom EVO platform and the Strata-X 96-well SPE Method Development (MD) Plate (Phenomenex). This completely automated approach can quickly and efficiently identify the optimal SPE sorbent, as well as providing walkaway routine processing to eliminate manual sample preparation.

Toxicology laboratories reduce costs and save time by automating Solid Phase Extraction sample processing

Development of an automated hydrolysis and SPE extraction method on a Freedom EVO platform, offering quantitative determination of opioids, cocaine and other metabolites in urine for forensic toxicology.

Posters

Efficient and Robust Workflow Solution for the Bioanalysis of Therapeutic Antibodies in Pre-Clinical Models

A sensitive and robust LB-MSIA workflow for the quantification of intact mAbs in rodent plasma on the Freedom EVO.

Tecan Journal Articles

Hands-free SPE method development in under two hours
[TJ 01/2016]

Combining the Freedom EVO positive pressure SPE workstation with the Phenomenex Strata-X 96-well SPE Method Development Plates offers a new paradigm in SPE method development for CROs and diagnostic labs, reducing development time from six to seven days to under two hours.

Large molecule bioanalysis simplified
[TJ 01/2016]

Thermo Fisher Scientific has developed innovative sample processing tools designed to simplify and accelerate analytical workflows. Offering automation-friendly affinity purification for proteins and antibodies, this provides a robust solution for high throughput preclinical research and development.

A helping hand for vitamin testing
[TJ 01/2015]

A Freedom EVO workstation is providing automated sample preparation for LC analysis of vitamins at the Medical Laboratories of the Reinier de Graaf Hospital, generating major time and cost savings and meeting the laboratory’s increasing throughput demands.

Automation allows simultaneous antimicrobial susceptibility testing and MALDI-TOF sample preparation for bacterial identification
[TJ 01/2015]

A Freedom EVO-based platform for automated antimicrobial susceptibility testing and MALDI-TOF sample preparation is proving beneficial to the Medical Laboratory Bremen, offering enhanced reproducibility compared to manual processes for more accurate results.

A RECIPE for success
[TJ 03/2014]

Tecan and RECIPE have automated analysis of vitamin D and immunosuppressants using a Freedom EVO platform and ClinMass® LC-MSMS Complete Kits, helping to meet the demand for high throughput sample preparation for mass spectrometry.

Transforming therapeutic drug monitoring for transplant patients
[TJ 02/2014]

A Freedom EVO workstation is being used by the University Hospital of Padova to prepare LC-MSMS samples for immunosuppressant drug monitoring in transplant patients.

Meeting the high throughput demands of mass spectrometry sample preparation
[TJ 03/2013]

ADPEN Laboratories has invested in a Freedom EVO liquid handling platform for mass spectrometry sample preparation.
For research use only.