Autoimmunity

Autoimmune disease are chronic inflammatory processes. They can be either organ-specific or systemic in nature. Autoimmune diseases predominantly affect women and correlate with the production of disease-associated autoantibodies. The impact of autoimmune diseases on the cost of healthcare and effective treatment underline the importance of accurate and reliable methods for diagnosis, prognosis and monitoring autoimmune diseases.




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Tab 01 / Application fields
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Myasthenia gravis

Myasthenia gravis (MG) is caused by the failure of neuromuscular signal transmission. To confirm the diagnosis of MG the determination of acetylcholine receptors (ARAb) and muscle-specific receptor tyrosine kinase (MuSK) autoantibodies is needed.

The ARAb Radioimmunoassay can be used as a method for the measurement of autoantibodies in serum of 80-90 % of patients with generalized myasthenia gravis and in 55-70 % of patients with ocular myasthenia. In 10-20 % of the patients with generalized MG, and in up to 50 % of the patients with ocular MG these autoantibodies cannot be detected. In these cases the disease is commonly referred to as seronegative MG (SNMG). The antibodies to the muscle-specific receptor tyrosine kinase can be detected and measured via MuSK-Ab ELISA.

Agrin-induced clustering of acetylcholine receptors via MuSK

Agrin-induced clustering of acetylcholine receptors via MuSK

~ 50 % of all seronegative MG patients is MuSK positive

~ 50 % of all seronegative MG patients is MuSK positive

Coeliac disease

The immune-mediated inflammatory process following ingestion of wheat, rye, or barley proteins occurs in genetically susceptible individuals. Coeliac disease is associated with a variety of autoantibodies, including tissue transglutaminase (tTG) and gliadin antibodies.

Although the IgA isotype of these antibodies usually predominates in coeliac disease, individuals may also produce IgG isotypes. The most sensitive and specific serologic test is the tTG-IgA test.




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Tab 02 / Literature
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ELISA

Selected ELISA reagents from our wide range of products for your Freedom EVOlyzer.

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Tab 03 / Request a Quote!
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Picture
Product
Prod. No.
Price (US$)
Quantity
Order

ANA HEp-2 Screen ELISA

Incubation time 3 x 30 min | Standard range cut-off control | Specimen / Volumes 10 µL Serum | Kit Size 12 x 8 | Substrate / isotype TMB 450 nm |..

Incubation time 3 x 30 min | Standard range cut-off control | Specimen / Volumes 10 µL Serum | Kit Size 12 x 8 | Substrate / isotype TMB 450 nm | Regulatory EU: CE

ANA-HEp2 Screen ELISA is a solid phase enzyme immunoassay for the combined qualitative detection of IgG antibodies against HEp2 cells in human Serum. Protocol available for the open ELISA systems Freedom EVOlyzer® and ThunderBolt®.


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RE70151

CIC-C1q ELISA

Incubation time 2 x 30 min., 1 x 15 min. | Standard range 0 - 64µgEq/ml | Specimen / Volumes 10 µL Serum, plasma | Kit Size 12 x 8 | Substrate /..

Incubation time 2 x 30 min., 1 x 15 min. | Standard range 0 - 64µgEq/ml | Specimen / Volumes 10 µL Serum, plasma | Kit Size 12 x 8 | Substrate / isotype TMB 450 nm | Regulatory EU: CE

ELISA for the quantitative determination of CIC-C1q in human Serum or plasma. Circulating immune complexes have been reported to show correlation with disease activity in that higher levels are reported during active phases of the disease.

Protocol available for the open ELISA systems Freedom EVOlyzer® and ThunderBolt®.


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DM59211

MuSK-Ab ELISA

Incubation time 3 x 1h, 1 x 30 min | Standard range 0 - 12 U/ml | Specimen / Volumes 10 µL Serum | Kit Size 12 x 8 | Substrate / isotype PNPP 405 nm..

Incubation time 3 x 1h, 1 x 30 min | Standard range 0 - 12 U/ml | Specimen / Volumes 10 µL Serum | Kit Size 12 x 8 | Substrate / isotype PNPP 405 nm | Regulatory EU: CE

The world’s first commercially available ELISA for measuring MuSK autoantibodies. Excellent sensitivity of 95.8 % and specificity of 100 %. Qualitative (cut-off) and quantitative (standard curve) evaluation of results. High-performance assay: low cross-reactivity, good linearity and high precision. MuSK-Ab ELISA is a quantitative assay and able to differentiate positive titers and therefore enhances the clinical utility for patient management (disease monitoring). Highly purified recombinant antigen is used for the ELISA. Total assay 4-4,5 h.

Protocol available for the open ELISA system Freedom EVOlyzer®.


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RE51021

Transglutaminase (tTG) IgA ELISA

Incubation time 3 x 30 min | Standard range 0 - 300 U/mL, cut-off 15 U/mL | Specimen / Volumes 10 µL Serum | Kit Size 12 x 8 | Substrate / isotype..

Incubation time 3 x 30 min | Standard range 0 - 300 U/mL, cut-off 15 U/mL | Specimen / Volumes 10 µL Serum | Kit Size 12 x 8 | Substrate / isotype TMB 450 nm | Regulatory EU: CE

The ELISA is intended for the quantitative or qualitative determination of IgA antibodies in human Serum, directed against tTG (tissue Transglutaminase). The test is fast (incubation time: 30 / 30 / 30 minutes) and flexible (divisible solid phase, ready to use reagents). Six calibrators allow quantitative measurements; a negative and a positive control check the assay performance.

Protocol available for the open ELISA system Freedom EVOlyzer®.


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30132295

Transglutaminase (tTG) IgG ELISA

Incubation time 3 x 30 min | Standard range 0 - 300 U/mL, cut-off 15 U/mL | Specimen / Volumes 10 µL Serum | Kit Size 12 x 8 | Substrate / isotype..

Incubation time 3 x 30 min | Standard range 0 - 300 U/mL, cut-off 15 U/mL | Specimen / Volumes 10 µL Serum | Kit Size 12 x 8 | Substrate / isotype TMB 450 nm | Regulatory EU: CE

The ELISA is intended for the quantitative or qualitative determination of IgG antibodies in human Serum, directed against tissue Transglutaminase (tTG). The test is fast (incubation time: 30 / 30 / 30 minutes) and flexible (divisible solid phase, ready-to-use reagents). Six calibrators allow quantitative measurements; a negative and a positive control check the assay performance.

Protocol available for the open ELISA systems Freedom EVOlyzer® and ThunderBolt®.


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30132293

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Find here selected products. Protocols for application support are available. The combined use of assays, process script and open system instrument (e.g. EVOlyzer®, ThunderBolt®) has to be validated individually on site by each laboratory. Interchangeability is only valid within same lot numbers for the single components.