The multi-tasker of the innate immune system!
Over years, HMGB1 has increasingly attracted the attention of all kinds of researchers. It is one of the most intriguing molecules within the complete arsenal of proteins of the innate immune system as HMGB1 is either actively secreted by immune cells, or passively by injured cells as the cell’s immediate cry for help. An automate friendly version will be launched by October 2019.
HMGB1 is a nuclear protein that can bind and bend DNA, but it can also be released to the extracellular environment where it exerts additional functions.
The unraveling of the post-translational modifications has led to a better understanding of the mechanism of its translocation and its function within the immune system. It will now also allow more in-depth studies into the role of HMGB1 in numerous pathologies, including
- Autoimmune diseases
- Cardial infarction
- ... any inflammatory process