Immunology

Immunology is the medical field that addresses the study of physiological functioning of the immune system in health and disease.

Dysfunctions of the immune system are generally termed “immune disorders”. These types of disorders can be characterized in different ways.

First by the component(s) of the immune system affected, second whether the immune system is either overactive or underactive, third whether the condition is congenital or acquired. The immune system can be divided into the ancient, primitive innate immune system and (in vertebrates) the adaptive immune system. This can be further divided into humoral (antibody response) and cell-mediated components.

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Neopterin

Neopterin is a low molecular weight molecule belonging to the chemical group known as pteridines. It plays a major role in the adaptive, cell mediated immune response. It is synthesised by cellular immune reaction of macrophages and dendritic cells upon stimulation with the cytokine interferon-beta and as a consequence released. Neopterin has a higher stability in body fluids which makes the sample handling and measurement easier compared to other cytokines.

 

The low molecular weight, let neopterin molecules rapidly pass the intravasal area, where it is released into urine after glomerular filtration. The half-life period in human bodies is only affected by renal excretion. So neopterin values reflect the totality of immunological processes for monocytes/macrophages and dendritic cells and can be seen as a general marker of immune activity.

HMGB1 biology by the current state of scientific knowledge
HMGB1 biology by the current state of scientific knowledge

HMGB1

The multi-tasker of the innate immune system!

Over years, HMGB1 has increasingly attracted the attention of all kinds of researchers. It is one of the most intriguing molecules within the complete arsenal of proteins of the innate immune system as HMGB1 is either actively secreted by immune cells, or passively by injured cells as the cell’s immediate cry for help. An automate friendly version will be launched by October 2019.

HMGB1 is a nuclear protein that can bind and bend DNA, but it can also be released to the extracellular environment where it exerts additional functions.

The unraveling of the post-translational modifications has led to a better understanding of the mechanism of its translocation and its function within the immune system. It will now also allow more in-depth studies into the role of HMGB1 in numerous pathologies, including

  • Autoimmune diseases
  • Sepsis
  • Cancer
  • Diabetes
  • Cardial infarction
  • Stroke
  • ... any inflammatory process
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ELISA

Selected ELISA reagents from our wide range of products for your Freedom EVOlyzer.

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ELISA for your ThunderBolt

Selected ELISA reagents from our wide range of products for your ThunderBolt.

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CRP high sensitive (C- reactive protein) ELISA

Incubation time 2 x 30 min, 1 x 10 min | Standard range 0.4 - 10 µg/mL | Specimen / Volumes 10 µL Serum, plasma | Kit Size 12 x 8 | Substrate /..

Incubation time 2 x 30 min, 1 x 10 min | Standard range 0.4 - 10 µg/mL | Specimen / Volumes 10 µL Serum, plasma | Kit Size 12 x 8 | Substrate / isotype TMB 450 nm | Regulatory EU: CE

hsCRP is the novel and evolving biomarker which provides a most useful predictive indicator for subsequent cardiovascular events. For measuring CRP in the low range as a risk marker for cardiovascular diseases, IBL International offers the high sensitivity CRP ELISA. Serum concentration of CRP increases significantly in cases of both infectious and noninfectious inflammation, of tissue damage and necrosis and in the presence of malignant tumors. The CRP level increases dramatically following microbial infections, and this can be particularly helpful for the diagnosis and monitoring of bacterial septicemia in neonates and other immunocompromised patients at risk. The hsCRP ELISA by IBL International is for the quantitative high sensitive determination of C-Reactive Protein in human Serum and plasma. The standards of the ELISA kit are calibrated against the NIBSC International Standard 85/506.

Protocol available for the open ELISA system ThunderBolt®.


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EU59151

Neopterin ELISA

Incubation time 1 x 1.5 h, 1 x 10 min | Standard range 1.35 - 111 nmol/L | Specimen / Volumes 20 µL Serum, plasma, urine | Kit Size 12 x 8 |..

Incubation time 1 x 1.5 h, 1 x 10 min | Standard range 1.35 - 111 nmol/L | Specimen / Volumes 20 µL Serum, plasma, urine | Kit Size 12 x 8 | Substrate / isotope TMB 450 nm || Regulatory EU: CE

The determination of neopterin levels in human body fluids offers a useful and innovative tool to monitor diseases associated with the activation of cell-mediated immunity. IBL International ELISA usage minimizes the „diagnostic window phase“ (HIV, Hepatitis), and detect unscreened or emerging pathogens (Malaria, EBV, Parvovirus,…). The ELISA test has excellent test characteristics like fast and easy performance (ready to use reagents) as well as excellent reproducibility, linearity and recovery. Furthermore, the ELISA kit is processable on open ELISA systems.

Protocol available for the open ELISA system Freedom EVOlyzer ®.


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RE59321

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Find here selected products. Protocols for application support are available. The combined use of assays, process script and open system instrument (e.g. EVOlyzer®, ThunderBolt®) has to be validated individually on site by each laboratory. Interchangeability is only valid within same lot numbers for the single components.