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Neurodegeneration

Neurodegeneration or neurodegenerative diseases are a group of disorders that are characterized by progressive loss of structure respective function of neurons, including their death.

Most known neurodegenerative diseases are Alzheimer’s disease, Parkinson’s disease, Multiple sclerosis and Amyotrophic Lateral Sclerosis. Yet, research in the field of neurodegeneration elucidates many more often overlapping diseases that have similar cellular and sub-cellular pathogenic mechanisms.




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Tab 01 / Application fields
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Alzheimers Diagnostics

Alzheimer's disease (AD), a neurodegenerative disease leading to dementia, can be characterized by 3 hallmarks, which are formation of Amyloid-beta plaques, TAU fibrils and loss of neurons and synapses, leading to a significant brain volume reduction. The first 2 hallmarks lead to the fact that measuring these proteins in CSF is a valuable tool to support the diagnosis of Alzheimer's disease.

To assess Amyloid-beta pathology in AD more recent clinical research has shown that the determination of the Amyloid-beta ratio of Amyloid-beta (1-42)/Amyloid-beta (1-40) significantly improves the diagnostic value towards AD (Figure 1). Furthermore as fibril formation of TAU proteins is characterized by hyperphosphorylation, the determination of either phosphoTAU or the non-phosphorylated TAU fraction confirms the TAU pathology in AD.

Amyloid-beta ratio of Amyloid-beta (1-42) to Amyloid-beta (1-40)

The Amyloid-beta ratio of Amyloid-beta (1-42) to Amyloid-beta (1-40) significantly improves the accuracy of concordant samples in comparison to PiB from 74.9% to 89.4% (Lewczuk et al. J Alzheimers Dis. 2017;55(2):813-822.)

Schematic illustration of neurofilament subunits

Schematic illustration of neurofilament subunits

Research of axonal destruction

Neurofilaments are the backbone of the neuronal cytoskeleton. Neurofilament light is found to be elevated in neurodegenerative disorders that are associated with the destruction of white matter (substantia alba). Typically these are:

  • Parkinson's disease (PD)
  • Multiple Sclerosis (MS)
  • Amyotrophic Lateral Sclerosis (ALS)

Further research in neurodegeneration

Yet, as the field of neurodegeneration still has much more to be discovered and understanding of disease mechanisms has still to be completely understood, we offer a large range of assays to enable research in this field.

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Tab 02 / Literature
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Product Flyers

ELISA

Selected ELISA reagents from our wide range of products for your Freedom EVOlyzer.

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ELISA for your ThunderBolt

Selected ELISA reagents from our wide range of products for your ThunderBolt.

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Neurodegeneration

Facilitate your workloads with automated ThunderBolt & ELISA solution. Suggested neurodegeneration panel worksheet for ThunderBolt®. Determin up to 4 dementia markers. List of available products.

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Find here selected products. Protocols for application support are available. The combined use of assays, process script and open system instrument (e.g. EVOlyzer®, ThunderBolt®) has to be validated individually on site by each laboratory. Interchangeability is only valid within same lot numbers for the single components.