Incubation time 1 x 1h, 1 x 45min, 1 x 30min, 1 x 15min | Standard range 100 - 10000 ng/L | Specimen / Volumes 50 µL CSF | Kit Size 12 x 8 |..
Incubation time 1 x 1h, 1 x 45min, 1 x 30min, 1 x 15min | Standard range 100 - 10000 ng/L | Specimen / Volumes 50 µL CSF | Kit Size 12 x 8 | Substrate / isotype TMB 450 nm | Regulatory EU: CE
The NF-Light® (Neurofilament light) ELISA allows fast quantification of the neurofilament light chain. Neurofilament light is found to be elevated in neurodegenerative disorders that are associated with the destruction of white matter, such as Parkinson's disease (PD), Multiple sclerosis (MS) and Amyotrophic lateral sclerosis (ALS).
The assay was developed by UmanDiagnostics, a company focusing on the development of tools for the determination of neurological and traumatic injuries.
Neurofilaments are the backbone of the neuronal cytoskeleton. Inside the axons, phosphorylation and dephosphorylation of the neurofilaments regulate the expansion and contraction of the microtubules. The neurofilament light chain is the most common isoform compared to medium and heavy chain. It is rapidly released after axonal destruction and remains highly stable (at least for 8 days, even at room temperature).
The NF-Light® (Neurofilament light) ELISA is exclusively distributed by IBL International. Protocol available for the open ELISA system ThunderBolt®.