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Compound management

Throughput and accuracy are everything for compound management, so we’ve engineered a range of compact automation solutions based on the Freedom EVO® and Fluent® workstations. Three arms work in parallel to optimize key parts of the process, with Fluent offering unrivalled plate capacity. Discover instruments that speak the language of your laboratory, making compound management more simple and efficient.

Overview

Whether you are looking for a highly flexible, proven solution or unsurpassed speed for plate formatting and copying, we are confident that the compound management platforms we offer perfectly fit today’s needs.

Key benefits

  • Automated compound weighing
  • Comprehensive sample and plate tracking
  • Graphical software allows system operation without automation expertise
Blog_How_to_become_fluent_in_Compound_mgmt

Find out how Electronics/Lab Auomation at Boehringer Ingelheim, Germany uses Fluent for a project called Compound in Plate Dissolution Station (CIPDIS).

Read the blog article or watch the full video.

Sample weighing

Running out of patience? Free yourself to do the science and let an automated platform do the weighing for you. Tecan’s Automated Weighing Stations provide a walkaway solution to one of the most time-consuming tasks regularly performed in analytical laboratories.

Highlights

  • Hundreds of samples weighed and resuspended without user interaction
  • Easy automation of weight/volume- and concentration-based resuspensions on a single instrument
  • Full sample tracking
  • The capability to use 2D barcoded tubes
  • The option to integrate both sonication and vortexing
  • Carry out sample distribution and standard curve set-up on the same workstation
  • Integrate plate sealing and tube capping into the process
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Weigh Station Wizard

Tecan combines hardware and software to provide a complete solution for weighing and dissolving compounds.

The Weigh Station Wizard software efficiently automates the entire dissolution process on the Freedom EVO platform.

Highlights

  • Weighing of empty vials (Tare)
  • Holding the data in a database
  • Re-weighing the same vial once a sample is added (Weigh Solid)
  • Using the data to assign a sample weight
  • Calculating the correct amount of solvent to add
  • Addition of solvent and mixing (Dilute)
  • Graphical interface guides the user through the processes of taring, weighing and diluting the compounds
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Sample dissolution and resuspension

Do you need fast sample dissolution or resuspension for your compound management applications? Tecan and Covaris have combined forces to automate the Adaptive Focused Acoustics™ (AFA) technology.

Highlights

  • Integration of the Covaris S-Series or E-Series with the Freedom EVO
  • Wavelength is scalable and therefore focused on the sample
  • Fast dissolution helps to reduce sample degradation
  • Improved consistency of screening data due to complete sample resuspension
  • Speed up compound thawing and save time
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Sample tracking

Freedom EVOware® Sample Tracking makes it easier than ever to track your samples. Full process security includes tracking of samples and pipetting actions, with the advantage of simplified LIMS integration. Simply register the sample you wish to track, and choose from a variety of standard plate- and sample-based reports for complete process security throughout your applications.

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Overview

Compound libraries can contain hundreds of thousands of samples to millions and management of these can be a full-time job even for smaller operations. Tecan offers flexible solutions for efficient library management.

Key benefits

  • Eliminate repetitive, tedious pipetting processes
  • Set up complex compound dilution plates
  • Benefit from robust assay results

Dart NeuroScience in the US said:
"Where we could previously generate 16 compound plates at a time, we can now produce 32 in parallel, and in a short time frame. And it’s even better for dilutions; where we could previously create about 20 single dilutions in parallel, we can now do 56 in duplicate. It’s basically tripled the speed of most of our protocols."
Read more in "Darting from plate to plate"

Plate reformatting

Since microplates became the storage and assay format of choice for drug discovery, there has been a need to transfer samples from one plate to another. Fast and efficient reformatting of microplates is also essential for assay miniaturization, significantly reducing the cost of compounds and reagents.

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Highlights

  • Teach-free reformatting from 384- to 1,536-well plates on the Fluent platform
  • Capacity and speed for higher throughput and longer walkaway times
  • Integration of Stacker and/or Carousel to further increase workdeck capacity
  • Choice of reformatting methods
  • On-the-fly adapter change for 96- or 384-channel pipetting

Choose your layout

Different reformatting methods available: 96- to 384-well plates, or 384- to 1,536-well plates.

For 96- to 384-well reformatting

  • Use of the Multiple Channel Arm 384 and ‘96 out of 384’ adapter plate with disposable tips guarantees highly comparable results
  • Extended Volume Adaptor (EVA) for the Multiple Channel Arm enables the use of filtered disposable tips, if desired
  • Use of the EVA adapter plate with nested Multiple Channel Arm disposable tips maximizes workdeck capacity

Tube-to-plate transfer

Not every compound library comes in plates, but that’s no problem with the eight-channel Flexible Channel Arm with adjustable tip spacing.

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Choose fixed tips to

  • Dispense extra low volumes
  • Save costs on consumables
  • Pipette from deep tubes or bottles
  • Use DMSO as system liquid for fast dissolution of compounds
  • Pierce septa and plate seals

Choose disposables tips to

  • Benefit from optimal precision pipetting
  • Eliminate time-consuming wash steps
  • Offer a choice of liquid-displacement or air-displacement pipetting for maximum flexibility

Plate replication

Some things just have to be done, even if they are tedious and time consuming. When it comes to replicating assay plates, Fluent – with its Multiple Channel Arm 96- and 384-channel pipetting heads – is an eager beaver. It delivers incredibly fast, highly precise pipetting down to 0.25 µl, leaving you free to walk away and use the time to do really interesting things.

Highlights

  • Fluent is teach-free for plate formats up to 1,536 wells
  • On-the-fly adapter plate exchange between disposable and washable steel tips
  • Reuse disposable tips by leaving them attached to the adapter plate between pipetting stages, reducing costs
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Set up serial dilutions for IC50/EC50

Manual pipetting of serial dilutions is boring and time consuming. Tecan offers different solutions to set up your dilution series more precise, simpler, faster and automated.

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Contact-free into any well

Take advantage of non-contact dispensing of any dose – from picoliter to microliter volumes – directly into any well of your assay plate. Tecan’s D300e Digital Dispenser with HP’s Direct Digital Dispensing technology is one of the fastest ways to set up dose-response curves and drug combination studies.

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Double the speed of serial dilutions

Unleash the serial dilution champion by fetching rows or columns of tips. Parallel pipetting of up to 64 channels allows serial dilutions to be performed twice as fast as before.

Highlights

  • Broad pipetting range, from 0.25 to 500 µl for one-step dilutions
  • Flexible tip pick-up – rows or columns
  • Dynamic addition of standards and controls
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The High-Throughput Screening Facility of the JP Sulzberger Columbia Genome Center said:
"The system is highly intuitive, and has proved very popular. We are increasingly finding that people from outside the facility are coming in to use the HP D300 for their own projects. It provides a simple method of generating dose-response curves that eliminates serial dilution, and is ideal for our drug combination studies. The instrument does exactly what we want it to do, fulfilling our need for an instrument that staff can just walk up to and use straight away for small molecule studies, with very little set-up time required. I am really happy with the HP D300."
Read more in "Rapid generation of dose-response curves for high throughput screening"

Daughter plates

Some things just have to be done, even if they are tedious and time consuming. When it comes to replicating assay plates, Fluent – with its Multiple Channel Arm 96- and 384-channel pipetting heads – is an eager beaver. It delivers incredibly fast, highly precise pipetting down to 0.25 µl, leaving you free to walk away and use the time to do really interesting things.

Highlights

  • Fluent is teach-free for plate formats up to 1,536 wells
  • On-the-fly adapter plate exchange between disposable and washable steel tips
  • Reuse disposable tips by leaving them attached to the adapter plate between pipetting stages, reducing costs
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The Compound Management Group at Novartis said:
"The CMG purchased two identical DRP systems, designed for automated plating of compounds from Matrix storage tube racks into 96-, 384- and 1,536-well destination plates... we were able to process 5,000 hits per DRP module – 10,000 per day – increasing our throughput five- to six-fold compared to our old SolArs system…"
Read more in "Speeding up drug discovery"

Hit picking

Tecan’s liquid handling platforms are widely used for hit-picking (cherry-picking) applications in screening and compound logistics laboratories worldwide. The combination of a flexible eight-channel pipetting arm, a broad dynamic pipetting range, a robotic microplate handler and the ability to integrate a wide variety of devices makes Tecan’s automated platforms ideal tools to address hit-picking needs.

Highlights

  • Choose your Hit-Picking liquid handling platform, Freedom EVO or Fluent
  • Integrate barcode printing, labeling and reading devices for effortless sample tracking
  • Large plate storage capacity
  • Automated lid handling
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Application Notes

Since microplates became the storage and assay format of choice for drug discovery, there has always been a need to transfer samples from one plate format to another. This application note describes the automated reformatting of microplates, from 96 up to 1,563 wells.

This application note describes the easy automation of hit-picking and IC50 assay plate generation from tubes and microplates.

Tecan Journal Articles

Dart NeuroScience specializes in the development of novel therapeutics targeting neurological disorders. In addition to performing multiple tasks on several Freedom EVO workstations, the company uses Tecan’s Fluent Laboratory Automation Solution to manage the throughput of assay plate generation.

The HP D300 Digital Dispenser has enabled Translational Drug Development in the USA to automate its workflows, increasing sample throughput and the number of cell line panels handled, as well as enhancing workflow efficiency.

The HP D300 Digital Dispenser is enabling researchers at the Columbia Genome Center’s High-Throughput Screening Facility to quickly and simply create dose-response curves for combinations of up to nine compounds, allowing rapid generation of EC 50 data for faster experimental progress.

GlaxoSmithKline’s quest for improved anti-malarial treatments has been revolutionized by the speed and reliability of the HP D300 Digital Dispenser. This innovative system has increased throughput for standard drug titrations and enabled combinations of candidate compounds to be tested much more easily.

Production of dose-response plates and cherry-picking are essential steps in early drug discovery to enable testing of many thousands of compounds. Researchers at Novartis are benefitting from the automated plate generation capabilities of two customized systems based on Freedom EVO 200 platforms, increasing sample throughput to over 10,000 compounds a day.

French pharmaceutical company Galderma specializes in the development of drugs for a variety of dermatological complaints, including acne, rosacea and psoriasis, and has chosen a customized Freedom EVO® 200 liquid handling workstation to manage its huge library of compounds used in high throughput screening.

Scientists at AstraZeneca UK, in partnership with Tecan, are developing a fully automated solubility screening platform, using a Freedom EVO 200 liquid handling workstation integrated with a tailor-made data capture system, a novel pH flow cell carrier and a small footprint HPLC system.

For research use only