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Fluent® 

Laboratory Automation Solution

Tecan has reinvented automation with Fluent, a unique instrumentation concept built around the application-specific needs of your laboratory. Fluent breaks new ground, delivering more capacity and increased speed. The platform provides superior precision, throughput and walkaway time—making it easier to get more done, more confidently.

 

Your applications are our inspiration

Fluent was designed to meet the needs of various life science workflows, such as high throughput genomics, by combining high precision liquid handling - down to 200 nl - with straightforward set-up of normalization, sample transfer and reagent distribution using Smart Commands.

Its freely configurable architecture allows rapid integration of devices for DNA quantification and processing, and offers exceptional storage capacity for plates and tips.

Confidence comes from an instrument that is simply faster and more precise.

New Fluent enhancements

Robotic Gripper Arm for versatile tube and plate handling

Smoothly and quickly delivers labware—including plates and tubes—to the instrument’s pipetting arms and integrated devices without interrupting the pipetting process. Fluent's unique Finger Exchange System head automatically exchanges between tubes or plates and vertical or excentric plate handling.

Exceptional ease of use and enhanced process security

Built-in touchscreen interface guides users through daily tasks for fast, consistent operation. Integrated user management including method permissions, ensures secure protocols and optimizes selection for each user. Method Recovery functions allow process runs to be reinstated even following events such as power out or computer crash.

Sample identification (or tube and plate identification) and tracking allow safe and confident processing.

Read more

Simple and safe sample tracking

Fluent ID™ enables simple and safe, high capacity sample identification and tracking. This scalable and up-gradable tube identification module accommodates 192 to 768 sample tubes per batch, The efficient, user-centric load-and-go operation and support of limitless batch reloading ensures complete confidence and high productivity.

Read more

Choice of powerful liquid handling technologies

By offering a choice of both air- and liquid-displacement pipetting technologies, the Flexible Channel Arm provides unrivalled flexibility to suit the needs of your laboratory workflow. Increase productivity even further with Dual Flexible Channel Arms using both pipetting technologies on 16 separate pipetting channels.

FluentControl offers robust default liquid definitions and makes it easy to change parameters for any fluid.

 

Fluent highlights

Increased walkaway time

With its industry-leading deck and below deck arm access, Fluent can accommodate multiple devices without expanding its footprint. Enjoy true walkaway operation with the seamless integration of complementary peripherals all fully managed by FluentControl™.

Dynamic deck

Fluent’s patented Dynamic Deck™ allows the high capacity worktable to be freely configured and easily reconfigured. A lower deck level allows devices to be integrated into the deck space extending the vertical range even for bench top systems.

Faster more streamlined workflows

Three independent, task-specific arms move in parallel to simultaneously and efficiently automate methods. Sample preparation, labware movement to peripheral devices and plate to plate or reagent additions can all occur in parallel — maximizing workflow performance.

Next-generation process control

Fluent’s unique teach-free hardware and Path Finder™ move optimization technology deliver unmatched positional accuracy and precision for enhanced process security and peace-of-mind.

Easy programming and operation

FluentControl™ software simplifies even the most challenging applications. Use drag & drop interfaces, 3D graphics, and single Smart Commands to distribute reagents or transfer samples.

Flexibility to deal with the unexpected

Fluent’s Active Stop and Resume function enables the operator to instantly access the workdeck during a run—allowing set-up errors or omissions to be corrected—simply by opening the door.

Create wizard-like interfaces

The Application Toolkit provides a collection of commands allowing programmers to create ‘wizardlike’ interfaces to further simplify everyday operation of the workstation.

3D simulations

Eases development of new assays and enables you to visualize a program, test new assays without using reagents or consumables, and estimate timing accurately and precisely.

Method Approval

Prevent unauthorized changes to validated protocols with the Method Approval function. Once any change is done to the protocol by an operator it cannot be executed any more until a key operator approves the changes.

Save sample and reagent volumes

Adaptive Signal Technology™, a new generation of liquid level sensing, enables use of smaller sample volumes, minimizes the risk of errors and provides exceptional automated error handling.

Third-party device integration

FluentControl offers straightforward integration of third-party devices, with an ever-increasing library of drivers — including support of SiLA devices — and Zero-G one-touch teaching to simplify setup.

Enhanced productivity with Tecan consumables

Tecan offers a broad portfolio of high quality consumables — from disposable tips to troughs — in Tecan Standard, Tecan Pure and Tecan Sterile purity levels. Every product undergoes stringent testing to ensure reliable automation.

 

Become more fluent in Tecan’s revolutionary new automation solution by selecting from a library of resources.

Within the USA for research use only. Not for clinical diagnostics.

Laboratory automation solution for cell-based assays

With a broad range of features specifically designed to optimize the performance of cell-based and biochemical assays, Fluent enhances throughput, streamlines workflows and delivers more precise and reliable results.

By simplifying the handling of precious samples and seamlessly integrating with cell biology devices, Fluent automates your complex assays for greater productivity and confidence.

The simple way to take the complexity out of cell biology research

Watch Video


Click the video above to learn more about how Fluent speaks the language of your laboratory.

Accelerating your investigations

No matter what your area of cell-based assay research, Fluent can automate your entire workflow for greater
throughput, more reliable results and faster discoveries.

For more details on Fluent’s performance and capabilities for Cell-based assays, click on the following application notes.

Fully automated HDAC assays on the Fluent Laboratory Automation Solution

Easy automation for cell-based assays on the FluentTM laboratory automation solution

Easy automation of cell-based assays on the FluentTM laboratory automation solution

Easy automation of complex, two-plate protocol on the FluentTM laboratory automation solution

Easy automation of a biochemical assay on the FluentTM laboratory automation solution

High density screening on the Fluent™ laboratory automation solution

Introduction

The failure of preclinical drug entities is a major problem for pharmaceutical companies, accounting for substantial proportions of their precious R&D budgets. As a consequence, there is a need to bring compound toxicity testing into a high throughput environment similar to primary efficacy screening. Metabolism of drugs is a key factor in compound toxicity, and the cytochrome P450 (CYP) superfamily of enzymes – mainly expressed in the hepatocyte cells of the liver – play a very important role in this process. There are now a number of screening assays designed to be automated in a microplate format for medium throughput profiling of compounds which may induce or inhibit CYP activity. In this application note, we describe a 384-well microplate format lead generation method using three different CYP enzymes, illustrating a typical assay run in an ADME laboratory.

 

Fluent highlights

Exceptional ease of use

Fluent’s built-in touchscreen interface guides users through every task, making even the most sophisticated cell-based assays easy to run—ensuring fast, consistent, efficient operation.

More functionality in less space

Fluent’s industry-leading deck capacity minimizes plate transfers and reduces the time cells are outside of the incubator. Below-deck arm access offers expanded functionality and device integration without extending the instrument footprint.

Optimized cell protection

Fluent’s three, task-specific robotic arms work in parallel for faster processing, and offer automated lid handling to maintain sterility and minimize evaporation.

A complete walkaway solution

Fluent’s seamless integration with cell biology devices allows you to run every step of your workflow on a single instrument. From incubation to analysis, everything you need to store, transfer, manipulate and measure cellular samples has been brought together in a single, automated solution.

Complementary consumables

Tecan offers a broad portfolio of sterile consumables ideal for cell-based research. From disposable tips to troughs, every product undergoes stringent testing to ensure the precision, consistency and purity you need for reliable, reproducible assay results.

Exceptional performance from sample to results

Fluent integrates perfectly with the Infinite® M1000 PRO multimode plate reader, a detection platform that delivers outstanding flexibility, sensitivity and performance for every assay by offering free wavelength selection without the need of filters.

Cell Protection™ throughout wash cycles

Tecan’s HydroSpeed™ plate washer features extra-gentle wash settings that you can adjust to suit specific cells, microplates and applications, enabling you to achieve reproducible results even with weakly adherent cells.

Ideal cellular conditions

A clean environment can be maintained inside Fluent with the integration of a HEPA hood, allowing cells to be kept under sterile conditions when needed.

Simplicity and consistency

The touchscreen interface guides users through daily tasks. Optionally embed SOPs for every method for consistent operation.

Easy set up and operation

Programming and running even the most complex cell-based assays is quick and easy with FluentControl™ software.

Enhanced process security

Integrated user management controls method permissions. Operators can even set personalized favorites on the touchscreen.

Powerful liquid handling

FluentControl offers robust default liquid definitions and makes it easy to change parameters for any fluid.

Fluent videos

Industry-leading deck capacity minimizes plate transfers for optimum cell handling and protection.

Below deck device integration. Keeps footprint small.

Parallel arm movements maximize throughput and minimize the time cells are outside the incubator.

Complete pipetting flexibility simplifies even complex custom protocols.

Automatically switch between 96- and 384-channel pipetting during the course of a run.

Patented Path Finder™ technology automatically programs the fastest, most efficient route for every arm movement.

Barcode reading ensures efficient sample tracking and enhanced process security.

Fast, efficient tip collection adds to the instrument’s unparalleled speed and precision.

 
Accelerating your investigations

Become more fluent in Tecan’s revolutionary new automation solution by selecting from a library of resources.

No matter what your area of cell-based assay research, Fluent can automate your entire workflow
for greater throughput, more reliable results and faster discoveries.

Laboratory automation solution for compound management

A whole new level of throughput, flexibility and confidence

Designed to simplify compound management workflows, Tecan’s groundbreaking Fluent platform brings unsurpassed speed and flexibility to plate formatting and copying.

Throughput and accuracy are everything. So we’ve engineered a compact automation solution with three arms that work in parallel across a Dynamic Deck featuring unparalleled plate capacity.

Discover an instrument that speaks the language of your laboratory by making compound management more simple, efficient… and fluent.

 

A better way to manage compound management

For more details on Fluent’s performance and capabilities in Compound Management,
click on the following application notes.

For many years, small molecule drug discovery has relied on the evaluation of one compound against another compound.

Measurement of the activity of a small molecule against a target must be standardized, and this is achieved by determining the IC50 or EC50 value (half maximal inhibitory/effective concentration respectively) using dose-response curves.

To set up dose-response curves, compounds must be dissolved in a solvent to create solutions of varying concentrations, and DMSO has become the established solvent of choice.

Today, chemists provide the biologists or compound management teams responsible for producing the dose-response curves with compound solutions prepared in DMSO.

The workflow frequently begins with picking the key target compounds from a number of different microplates, generally referred to as hit-picking.

These key compounds have often been selected based on single concentration data from a high throughput screening (HTS) campaign.

For many years, small molecule drug discovery has relied on the evaluation of one compound against another compound.

Measurement of the activity of a small molecule against a target must be standardized, and this is achieved by determining the IC50 or EC50 value (half maximal inhibitory/effective concentration respectively) using dose-response curves.

To set up dose-response curves, compounds must be dissolved in a solvent to create solutions of varying concentrations, and DMSO has become the established solvent of choice. Today, chemists provide the biologists or compound management teams responsible for producing the dose-response curves with compound solutions prepared in DMSO.

The workflow frequently begins with picking the key target compounds from a number of different microplates, generally referred to as hit-picking.

These key compounds have often been selected based on single concentration data from a high throughput screening (HTS) campaign.

 

Fluent highlights

More functionality and flexibility in less space

Industry-leading deck capacity offers high-density plate and tip storage in a small footprint. Unique, interchangeable design allows the modular worktable to be easily configured and reconfigured for plate reformatting, hit picking, tube-to-plate transfers, plate stamping and more.

Optimize performance with the industry’s most versatile multiple channel arm

Adjusts to 96, 384 and 1536 plate formats on the fly by swapping between 96- and 384-channel adapters. Makes it easy to optimize the performance of plate reformatting, stamping and diluting.

Flexible channel arm with fixed, steel tips broadens pipetting capabilities

Washable fixed tips made of coated steel offer reliable septa piercing and expand the instrument’s wide dynamic range down to below 0.5µl. The Flexible Channel Arm is also compatible with Tecan’s disposable tips to suit the requirements of different applications.

DMSO as system liquid for fast dilutions

Fixed tips can be primed for fast, automated compound dilutions or pre-filling of dilution plates. The steel tips can be washed from inside for ultimate system cleanliness and more reliable results.

Device integration for fully automated workflows

Seamlessly integrates with a broad range of complementary peripherals including 2D and plate barcode readers, high-density plate and tip stackers, plate sealers, and random access carousels. Run every step of your workflow on a single instrument for greater ease, convenience and productivity.

Robotic gripper arm for versatile tube or plate handling

Smoothly and quickly delivers labware—including plates and tubes—to the instrument’s pipetting arms and integrated devices without interrupting the pipetting process. Provides fast lid removal and replacement to minimize evaporation for reliable, reproducible results.

Exceptional ease of use

Built-in touchscreen interface guides users through daily tasks for fast, consistent, efficient operation. Customizable to suit specific users or applications, the software makes it easier than ever to generate reliable results while increasing throughput and productivity.

3D simulation for safe runs and compound conservation

Eases development of new assays and enables you to visualize a program, test new assays without using reagents or consumables, and estimate timing accurately and precisely.

Easy programming and operation

FluentControl™ software simplifies even the most challenging applications. Use drag & drop interfaces, 3D graphics, and single smart commands to distribute reagents or transfer samples.

Worklisting for greater speed and efficiency

Create everything from pipetting steps to hit picking processes in an Excel or text file and then run them with FluentControl software.

Enhanced process security

Integrated user management controls method permissions. Operators can even set personalized favorites on the touchscreen.

Powerful liquid handling

FluentControl offers robust default liquid definitions and makes it easy to change parameters for any fluid.

Extend the boundaries of automation

Fluent’s finger exchange system automatically swaps labware fingers on the fly – move tubes to balance and then plates to a centrifuge or storage device.

Reduce risk and increase confidence

Even in the event of a power out or computer crash FluentControl reinstates the interrupted run and presents clear directions to the operator to restart thus saving time and reagents.

Increase hit picking productivity

Combine two flexible channel arms on one system for the ultimate flexibility and speed in hit picking or tube to plate transfers.

Tube and plate security

Keep track of all labware and samples with several barcode reading options on the deck, on devices or using the Robotic Gripper Arm to carry the reader.

Fluent videos

Exchange Multiple Channel Arm adapter plates even with tips mounted for unrivaled speed and application flexibility

Versatile Multiple Channel Arm tip arrays enable double serial dilutions for greater productivity.

Flexible Channel Arm equipped with steel needles delivers fast, precise hit picking capabilities.

Multiple Channel Arm compatible with 1536 well plates for added efficiency.

 

Become more fluent in Tecan’s revolutionary new automation solution by selecting from a library of resources.

Within the USA for research use only. Not for clinical diagnostics.

Laboratory Automation Solution for Genomic Workflows

Fluent’s groundbreaking design delivers more capacity and increased speed for genomic workflows. This innovative solution offers superior precision, higher throughput and longer walkaway times, making it easier to get more done, more confidently.

 

 

A fast track to genomic results

Whether you want to increase throughput or reduce variability for nucleic acid purification,
quantification and normalization or reaction set-up,
Fluent provides greater throughput and more consistent results.

 

Fluent highlights

Intuition built right in

Built-in touchscreen interface guides users through daily tasks for fast, consistent operation. Integrated user management, including method permissions, ensures secure protocols and optimizes selection for each user.

Simply faster and more precise

Three independent, task specific arms move in parallel to simultaneously and efficiently automate methods. Sample preparation, labware movement to peripheral devices and plate-to-plate or reagent additions can all occur in parallel — maximizing performance.

Choice between liquid and air displacement technologies

By offering a choice of air and liquid displacement pipetting technologies, the Flexible Channel Arm provides unrivalled flexibilty to suit the needs of your laboratory workflow and increases productivity.

Save reagents and samples

Adaptive Signal Technology™, a new generation of liquid level sensing, enables the use of smaller sample volumes, minimizes the risk of errors and provides exceptional automated error handling.

Simpler Programming

FluentControl™ software simplifies even the most challenging applications. Use drag and drop interfaces, 3D graphics and single Smart Commands to distribute reagents or transfer samples.

Enhanced process security

Integrated user management controls method permissions. Operators even can organize personalized favorites on the desktop.

Flexibility to deal with the unexpected

Fluent’s Active Stop and Resume function enables the operator to instantly access the workdeck during a run — allowing set-up errors or omissions to be corrected — simply by opening the door.

Evolving with your needs

Dynamic Deck™ allows the worktable to be freely configured and easily be reconfigured.

Integration options

Magnetic separation for bead-based NAP and PCR clean-up

Integrated DNA quantification and normalization

Heating and cooling for incubation steps

Storage for longer unattended runs

Vacuum separation for filter-based purification formats

Sample tracking and barcode reading

Thermocycling

Protected environment with HEPA hood

Fluent videos

Parallel arm movements maximize throughput.

Barcode reading ensures efficient sample tracking and enhanced process security.

Exchange Multiple Channel Arm adapter plates, even with tips mounted, for unrivaled speed and application flexibility.

Complete pipetting flexibility simplifies even complex custom protocols.

 

Read more. See more. Learn more.

Become more fluent in Tecan’s revolutionary new automation solution by selecting from a library of resources.

Within the USA for research use only. Not for clinical diagnostics.

Laboratory automation software

The Fluent® Laboratory Automation Solution is a powerful platform, yet FluentControl keeps it simple with TouchTools™, a dedicated operator interface on the touchscreen of the instrument itself.

 

One great software, two powerful interfaces.

FluentControl is designed to empower scientists to build, optimize, and maintain their own assays, without the need for computer programming expertise. By separating the interactions of everyday workflows from the configuration of new assays, Tecan has created ideal tools for both.

Users can simply drag and drop commands to create a protocol, and use the 3D editor to configure their worktable elements and labware. A built-in auto-context check reviews the scripts as you create them – offering help if something might not work – and you can even preview your finished protocol in a 3D simulator, without wasting valuable reagents.

 

TouchTools – designed for every lab, every day.

For those who ‘press go’

Activities such as running assays and daily maintenance become as straightforward as using the smartphone in your pocket. Users intuitively know what to do next, without the need for additional explanations.

Clean presentation for everyday interactions

Touch-optimized interface for logging in, entering key values, reacting to user prompts, and more. And usability comes as standard – no extra programming is needed to make FluentControl user friendly.

Easier than making a Powerpoint® slide

Customize your user interface with pictures, videos and instructions specific to your lab or protocols – embedding your SOPs in every run. This will reduce the training necessary for new operators, and delight laboratory veterans by making their day-to-day tasks easier than ever before.

Simple interface. Heroic capabilities.

If your computer loses power in the middle of a method, TouchTools can guide the operator through recovering the run, showing what has already been done, what still needs to be done, and where everything should be.

FluentControl, take control.

Easy to set up – even for those new to automation

FluentControl is packed with features like Smart Commands, allowing you to program common tasks – such as distributing a reagent or transferring samples in replicate – with a single command.

For more information while editing, press F1 to open FluentControl's integrated help system.

User management and rights

The software’s optional user management offers three default user groups: operators, key operators and administrators. Operators can run the instrument, but cannot make changes to protocols. Key operators can ‘release’ new methods with the Method Approval feature. Administrators also have the capability to add new users and assign access rights.

Reduce sample and reagent waste

Adaptive Signal Technology™ enables the instrument to reliably detect miniscule volumes. Combining hardware accuracy with exact labware definitions, FluentControl can precisely model the interior of wells, calculate the detected volume and adapt the detection threshold to allow detection of volumes as small as 2 μl of water.

Pass data to and from FluentControl

Quickly and easily move data between FluentControl and external files using the ‘import/export variable’ commands. The worklisting feature even allows you to pipette directly from CSV files.

FluentControl also offers easy programmatic integration, such as executing external applications or running customized VB.NET code. The built-in API also allows you to execute protocols on the instrument and start/stop runs from your own specialty software.

The brain of the fluent laboratory automation solution

During a run, Fluent’s arms move with speed and grace, tracing the optimal paths around other modules. This is overseen in real time by Path Finder™, a patent pending technology that evaluates where everything is in three dimensions, including the shapes of devices and the changing height of disposable tip stacks during a run.

‘Teach-free’ means speed and reliability

After Installation Qualification, default carriers and labware can immediately be used in methods. No additional teaching is required thanks to a combination of the hardware’s mechanical accuracy and precision and the software’s carefully refined definitions.

Straightforward device positioning and integration

Using Zero-G positioning, you can simply slide an arm to the desired location by hand, then click ‘transfer’ and FluentControl will know exactly where it is.

Need to control that special device? FluentControl is ready for that too. Any SiLA-ready device can be controlled by default. Tecan has an extensive driver library available for other modules, too. Contact your local Tecan sales representative to learn more.

Special tools for troubleshooting

‘Snapshot’ gathers logs and system information when support is needed.

‘Remote Support’ allows you to connect with Tecan for troubleshooting.

‘Notification’ function automatically emails you if the system is interrupted.

‘Import/export method’ speeds up troubleshooting and allows easy transfer of methods between Fluent platforms.

 

Become more fluent in Tecan’s revolutionary new automation solution by selecting from a library of resources.

For research use only. Not for clinical diagnostics.

Application Notes

Histone acetylation and deacetylation play an important role in the regulation of gene expression. Histone deacetylases (HDACs) are a group of enzymes that remove acetyl groups from ε-N-acetyl lysine amino acids on histones, allowing them to wrap DNA more tightly.

This condenses the DNA structure, preventing transcription. Conversely, acetylation neutralizes the positive charges on the histones by changing amines into amides, decreasing their ability to bind DNA.

This decreased binding allows chromatin expansion, permitting genetic transcription to take place. 18 HDAC enzymes are currently known, which are either zinc-dependent or nicotinamide adenine dinucleotide-dependent (NAD-dependent).

They are grouped into four classes according to their homology to yeast proteins. Classes I, II and IV are considered ‘classical’ HDACs, and are inhibited by trichostatin A (TSA).

Due to the involvement of HDACs in various diseases and cancer development, there is now significant interest in selective HDAC inhibitors as potential therapeutic agents.

High density screening on the Fluent™ laboratory automation solution

Introduction

The failure of preclinical drug entities is a major problem for pharmaceutical companies, accounting for substantial proportions of their precious R&D budgets. As a consequence, there is a need to bring compound toxicity testing into a high throughput environment similar to primary efficacy screening. Metabolism of drugs is a key factor in compound toxicity, and the cytochrome P450 (CYP) superfamily of enzymes – mainly expressed in the hepatocyte cells of the liver – play a very important role in this process. There are now a number of screening assays designed to be automated in a microplate format for medium throughput profiling of compounds which may induce or inhibit CYP activity. In this application note, we describe a 384-well microplate format lead generation method using three different CYP enzymes, illustrating a typical assay run in an ADME laboratory.

For many years, small molecule drug discovery has relied on the evaluation of one compound against another compound.

Measurement of the activity of a small molecule against a target must be standardized, and this is achieved by determining the IC50 or EC50 value (half maximal inhibitory/effective concentration respectively) using dose-response curves.

To set up dose-response curves, compounds must be dissolved in a solvent to create solutions of varying concentrations, and DMSO has become the established solvent of choice. Today, chemists provide the biologists or compound management teams responsible for producing the dose-response curves with compound solutions prepared in DMSO.

The workflow frequently begins with picking the key target compounds from a number of different microplates, generally referred to as hit-picking.

These key compounds have often been selected based on single concentration data from a high throughput screening (HTS) campaign.

For many years, small molecule drug discovery has relied on the evaluation of one compound against another compound.

Measurement of the activity of a small molecule against a target must be standardized, and this is achieved by determining the IC50 or EC50 value (half maximal inhibitory/effective concentration respectively) using dose-response curves.

To set up dose-response curves, compounds must be dissolved in a solvent to create solutions of varying concentrations, and DMSO has become the established solvent of choice.

Today, chemists provide the biologists or compound management teams responsible for producing the dose-response curves with compound solutions prepared in DMSO.

The workflow frequently begins with picking the key target compounds from a number of different microplates, generally referred to as hit-picking.

These key compounds have often been selected based on single concentration data from a high throughput screening (HTS) campaign.

The ability to carry out cell-based G-Protein coupled receptor (GPCR) assays in high throughput is a key part of the drug discovery process.

Combining a Fluent laboratory automation solution configured for cell-based assays with the DiscoveRx PathHunter β-Arrestin human and ortholog GPCR assay kits gives users the power to run 384-well plate-based assays in high throughput.

This increased processing speed and capacity over current solutions, combined with extremely efficient use of laboratory space, makes this a superior system for cell-based assays.

The NCI-60 panel represents a wide diversity of common cancer-types and it is one of the most important tools in modern drug discovery for the identification of new anti-cancer compounds.

Although, the cell lines are commonly used in phenotypic assays for monitoring cell growth and survival, when combined with bioinformatics tools such as the NCI COMPARE database, NCI panel data can also provide a preliminary indication of the potential mechanisms of action for novel compounds.

Typically, large sets of compounds are initially tested at a single concentration.

Hits showing growth inhibition or cytotoxic properties are profiled in dose response format over multiple cell lines to establish compound potency and selectivity.

Epigenetics has played an important role in drug discovery for many years, but its importance has grown significantly recently due to the role epigenetic modifications can play in cancer and stem cell differentiation. Methylation is the principal epigenetic modification of DNA and of proteins known as histones, which package DNA into chromatin inside a cell.

Epigenetic modifications define how genetic information is read and used by cells and, through cell divisions, these epigenetic changes may last for the duration of the cell's life. They may also last for multiple generations, even though they do not involve changes in the underlying DNA sequence of the organism.

Epigenetic modifications can therefore be inherited, and are influenced by environmental factors, some of which can induce epigenetic signaling that may contribute to biological processes such as aging.

The Cisbio EPIgeneous cell-based assays enable direct measurement of methylation, demethylation, and total proteins on both adherent and suspension cells.

Tecan has re-invented automation with Fluent, a unique instrumentation concept built around the applicationspecific needs of your lab. Fluent breaks new ground, delivering more capacity and increased speed.

Epigenetics has played an important role in drug discovery for many years, but its importance has grown significantly recently due to the role epigenetic modifications can play in cancer and stem cell differentiation.

Methylation is the principal epigenetic modification of DNA and of proteins known as histones, which package DNA into chromatin inside a cell.

Epigenetic modifications define how genetic information is read and used by cells and, through cell divisions, these epigenetic changes may last for the duration of the cell's life. They may also last for multiple generations, even though they do not involve changes in the underlying DNA sequence of the organism.

Epigenetic modifications can therefore be inherited, and are influenced by environmental factors, some of which can induce epigenetic signaling that may contribute to biological processes such as aging.

The Cisbio EPIgeneous cell-based assays enable direct measurement of methylation, demethylation, and total proteins on both adherent and suspension cells.

Brochures

Designed for those who ‘press go’, daily activities such as running assays and routine maintenance become as straightforward as using the smartphone in your pocket. Users intuitively know what to do next.

Fluent was designed and built to increase throughput and productivity, enabling laboratories to get more done in less time – and less space.

Tecan’s groundbreaking Fluent platform brings unsurpassed speed and flexibility to plate formatting and copying. Throughput and accuracy are everything, so we’ve engineered a compact automation solution with three arms that work in parallel across a Dynamic Deck™ offering unmatched plate capacity. Discover an instrument that speaks the language of your laboratory, making compound management more simple, efficient… and fluent.

Seamless integration of cell-based assay technologies streamlines your workfl ows and simplifi es your laboratory life.

Fluent’s groundbreaking design delivers more capacity and increased speed for genomic workflows. This innovative solution offers superior precision, higher throughput and longer walkaway times. Get more done in less time, with greater confidence.

Technical Notes

Enhanced capacitive liquid level detection for increased reliability and reproducibility

Speed and throughput seem like logical reasons to acquire an automated liquid handling system but, for many users, the consistency of results is an even more valuable asset.

An unobtrusive, barely noticed feature – liquid level detection – plays a critical role in ensuring the reliability and consistency of the pipetting processes, but not all liquid level sensing technologies are created equal.

Tecan’s Adaptive Signal Technology is a new generation of capacitive liquid level sensing that does far more than just detect the liquid level in a microplate well; it can reliably distinguish between the true liquid level and bubbles, detect tip occlusions, prevent wells over-flowing, and offer new opportunities for in-process error handling.

Dead volumes costing you too much.

See how Fluent can help

Reducing the liquid dead volume is a highly desirable aspect of a liquid handling platform’s performance, particularly in the case of expensive reagents or precious scarce samples.

Minimizing the dead volume not only presents substantial reagent and sample cost savings, it can also result in more assays per unit volume, further decreasing labor costs and allowing more data per cycle.

Fluent Laboratory Automation Solutions with Adaptive Signal Technology™ (AST) advanced liquid level detection offer several synergistic benefits that reduce dead volume without compromising on the precision or accuracy of liquid transfers.