Scientific Citations

• Multiplexed precision genome editing with trackable genomic barcodes in yeast
• Common genetic variation drives molecular heterogeneity in human iPSCs
• The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin
• Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4
• A molecular roadmap for the emergence of early-embryonic-like cells in culture
• Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma
• Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis
• Automated Buildup of Biomimetic Films in Cell Culture Microplates for High-Throughput Screening of Cellular Behaviors
• Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity
• Vitamin B12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection
• Systematic Investigation of Transcription Factor Activity in the Context of Chromatin Using Massively Parallel Binding and Expression Assays
• Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140
• Fully Printed Infrared Photodetectors from PbS Nanocrystals with Perovskite Ligands
• Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes
• Convergent genomic signatures of domestication in sheep and goats
• A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors
• Small molecule screen in embryonic zebrafish using modular variations to target segmentation
• Survival of pancreatic cancer cells lacking KRAS function
• Improved genome recovery and integrated cell-size analyses of individual uncultured microbial cells and viral particles
• Selective Synthesis of the Human Drug Metabolite 5′-Hydroxypropranolol by an Evolved Self-Sufficient Peroxygenase
• Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins
• High-throughput microsphiltration to assess red blood cell deformability and screen for malaria transmission-blocking drugs
• Inducing and exploiting vulnerabilities for the treatment of liver cancer
• Intra-tumour diversification in colorectal cancer at the single-cell level
• Structural insight into allosteric modulation of protease-activated receptor 2
• Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
• A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity
• Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase
• An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
• Small-molecule targeting of brachyury transcription factor addiction in chordoma
• SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo
• Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors
• Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer
• TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma
• Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy
• Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia
• Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
• Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma
• Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response
• MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models
• Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients
• Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia
• Targeting the PI3K/mTOR Pathway in Lymphoma with PQR309 and PQR620: Single Agent Activity and Synergism with the BCL2 Inhibitor Venetoclax
• Additivity of inhibitory effects in multidrug combinations
• Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design
• Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis
• Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15
• Small-molecule allosteric inhibitors of BAX
• Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor
• Plasticity in binding confers selectivity in ligand-induced protein degradation
• Accessing chemical diversity from the uncultivated symbionts of small marine animals
• Light-controlled modulation of gene expression by chemical optoepigenetic probes
• A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
• Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases
• Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development
• Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response
• Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations
• Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
• Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
• TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
• Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum
• Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
• Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
• An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP
• Long-term expanding human airway organoids for disease modeling
• Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities
• Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state
• N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis
• Suramin inhibits cullin-RING E3 ubiquitin ligases
• The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents
• Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation
• KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition
• USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia
• Proliferation Markers Are Associated with MET Expression in Hepatocellular Carcinoma and Predict Tivantinib Sensitivity In Vitro
• A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines
• Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming
• Aurora A kinase inhibition destabilizes PAX3-FOXO1 and MYCN and synergizes with Navitoclax to induce Rhabdomyosarcoma cell death
• Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in KRAS-Mutant Cancer Cells
• Integrative Modeling Identifies Key Determinants of Inhibitor Sensitivity in Breast Cancer Cell Lines
• Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer
• High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells
• Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer
• Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure
• Global DNA Methylation Detection System Using MBD-Fused Luciferase Based on Bioluminescence Resonance Energy Transfer Assay
• A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma
• Fluorescence Based Microplate Assays for In Vitro Assessment of Mitochondrial Toxicity, Metabolic Perturbation, and Cellular Oxygenation
• Near-Infrared Illumination of Native Tissues for Image-Guided Surgery
• Daily magnesium fluxes regulate cellular timekeeping and energy balance
• Breaking the Permeability Barrier of Escherichia coli by Controlled Hyperporination of the Outer Membrane
• Impact of ozonisation on pro-health properties and antioxidant capacity of 'Honeoye'strawberry fruit
• An innovative protocol for schwann cells extracellular matrix proteins extraction
• Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain
• In-depth Characterization of Firefly Luciferase as a Reporter of Circadian Gene Expression in Mammalian Cells
• Reviving antibiotics: efflux pump inhibitors that interact with AcrA, a membrane fusion protein of the AcrAB-TolC multidrug efflux pump
• Novobiocin Susceptibility of MukBEF-Deficient Escherichia coli Is Combinatorial with Efflux and Resides in DNA Topoisomerases
• Neutrophil-derived proteases escalate inflammation through activation of IL-36 family cytokines
• Visualization of NO3 NO2 Dynamics in Living Cells by Fluorescence Resonance Energy Transfer (FRET) Imaging Employing a Rhizobial Two-component
• Candidacidal Activity of Selected Ceragenins and Human Cathelicidin LL-37 in Experimental Settings Mimicking Infection Sites
• A self-assembling RNA aptamer-based graphene oxide sensor for the turn-on detection of theophylline in serum
• Controlled extended octenidine release from a bacterial nanocellulose/Poloxamer hybrid system
• Detection of carbapenemase activity in Enterobacteriaceae using LC-MS/MS in comparison with the neo-rapid CARB kit
• Removal of antibiotics in wastewater by enzymatic treatment with fungal laccase
• Sequential Inactivation of Gliotoxin by theS-Methyltransferase TmtA
• Biofilm formation-defective mutants in Pseudomonas putida
• Targeted inhibition of WRN helicase by external guide sequence and RNase P RNA
• The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis
• Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
• Building enhancers from the ground up: a synthetic biology approach
• Antibiotic-induced replication stress triggers bacterial competence by increasing gene dosage near the origin
• Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
• Base motif recognition and design of DNA templates for fluorescent silver clusters by machine learning
• Combining phosphate and bacteria removal on chemically active filter membranes allows prolonged storage of drinking water
• CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer
• Increased levels of arginase in patients with acute hepatitis B suppress antiviral T cells
• Liposome-supported peritoneal dialysis for detoxification of drugs and endogenous metabolites
• Association of TNFSF15 polymorphism with irritable bowel syndrome
• Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation
• Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System
• Evolution in regulatory regions rapidly compensates the cost of nonoptimal codon usage
• H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery
• Molybdenum trioxide nanoparticles with intrinsic sulfite oxidase activity
• Layer-by-layer assembled antisense DNA microsponge particles for efficient delivery of cancer therapeutics
• Three-Dimensional Optical Mapping of Nanoparticle Distribution in Intact Tissues
• GMars-Q Enables Long-Term Live-Cell Parallelized Reversible Saturable Optical Fluorescence Transitions Nanoscopy
• CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model